02094ntm a2200265 a 4500 vtls000084820 KUKTEM 20251117113230.0 150113t2014 my a f m 000 0 eng d THE0003892(Local) 201905161507 shah 201501131300 fawwaz UMP TP156.C7 N33 2014 r Bc. Engku Nadia Engku Mat Nasir Solid phase transformation of carbamazepine-succinic co-crystal / Engku Nadia Engku Mat Nasir Kuantan, Pahang : UMP, 2014 xv, 37 p. : ill. ; 30 cm. + 1 CD-ROM Faculty of Chemical & Natural Resources Engineering Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014 Bibliography : p. 28-31 This paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed Crystallization Carbamazepine 0 0 0 1 10000 10000 2019-09-04 0 TP156.C7 N33 2014 r Bc. 0000092131 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 8668 | TP156.C7 N33 2014 r Bc. 0000092132 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 5117 5123 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5000*5020*5040*5200*6500*6501*9992