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  <titleInfo>
    <title>Introduction to statistical methods for clinical trials</title>
  </titleInfo>
  <name type="personal">
    <namePart>Cook, Thomas D.</namePart>
  </name>
  <name type="personal">
    <namePart>DeMets, David L.</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
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  <originInfo>
    <place>
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    <place>
      <placeTerm type="text">Boca Raton</placeTerm>
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    <publisher>Chapman &amp; Hall/CRC</publisher>
    <dateIssued>c2008</dateIssued>
    <dateIssued encoding="marc">2008</dateIssued>
    <issuance>monographic</issuance>
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  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
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  <physicalDescription>
    <form authority="marcform">print</form>
    <extent>xxiii, 439 p. : ill. ; 25 cm.</extent>
  </physicalDescription>
  <tableOfContents>Introduction to clinical trials -- Defining the question -- Study design -- Sample size -- Randomization -- Data collection and quality control -- Survival analysis -- Longitudinal data -- Quality of life -- Data monitoring and interim analysis -- Selected issues in the analysis -- Closeout and reporting</tableOfContents>
  <targetAudience authority="marctarget">specialized</targetAudience>
  <note type="statement of responsibility">edited by Thomas D. Cook, David L. DeMets</note>
  <note>Includes bibliographical references (p. 405-426) and index</note>
  <subject authority="lcsh">
    <topic>Clinical trials</topic>
    <topic>Statistical methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Clinical Trials as Topic</topic>
    <topic>methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Statistics as Topic</topic>
    <topic>methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Data Collection</topic>
    <topic>methods</topic>
  </subject>
  <subject authority="mesh">
    <topic>Research Design</topic>
  </subject>
  <relatedItem type="series">
    <titleInfo>
      <title>Texts in statistical science</title>
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  <identifier type="isbn">9781584880271 (hardback : alk. paper)</identifier>
  <identifier type="isbn">1584880279 (hardback : alk. paper)</identifier>
  <identifier type="uri">http://www.loc.gov/catdir/toc/ecip0726/2007036202.html</identifier>
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