02439nam a2200301 a 4500 vtls000049203 KUKTEM 20251117150251.0 101213t2010 flua f b 001 0 eng d 9781420073492 (hardcover : alk. paper) 201107140005 VLOAD 201103170806 Fida 201103091511 fauzi 201012131502 training UMP RS380 .K57 2010 Kisaalita, William Ssempa 3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening / William S. Kisaalita Boca Raton : CRC Press, 2010 xvii, 386 p. : ill. ; 24 cm. Includes bibliographical references and index (Publisher-supplied data) Biosensors and Bioassays -- Target-Driven Drug Discovery -- Comparative Genomics and Proteomics -- Comparative Structure and Function -- Chemical Microenvironmental Factors -- Spatial and Temporal Microenvironmental Factors -- Material Physical Property and Force Microenvironmental Factors -- Proteomics as a Promising Tool in the Search for 3D Biomarkers -- Readout Present and Near Future -- Ready-to-Use Commercial 3D Plates -- Challenges to Adopting 3D Cultures in HTS Programs -- Cases for 3D Cultures in Drug Discovery -- Ideal Case Study Design "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher Pharmaceutical biotechnology Biosensors High throughput screening (Drug development) Biosensing Techniques methods Cells, Cultured Drug Discovery 0 0 0 0 10000 10000 2019-09-04 405.90 0 RS380 .K57 2010 0000054399 2019-09-04 00:00:00 1 405.90 2019-09-04 OPEN VIRTUA40 54850 54856 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5040*5050*5200*6500*6501*6502*6503*6504*6505*9991