microtissue engineering for high throughput screening Kisaalita, William Ssempa creator text bibliography flu Boca Raton CRC Press 2010 monographic eng

print

xvii, 386 p. : ill. ; 24 cm. "This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher (Publisher-supplied data) Biosensors and Bioassays -- Target-Driven Drug Discovery -- Comparative Genomics and Proteomics -- Comparative Structure and Function -- Chemical Microenvironmental Factors -- Spatial and Temporal Microenvironmental Factors -- Material Physical Property and Force Microenvironmental Factors -- Proteomics as a Promising Tool in the Search for 3D Biomarkers -- Readout Present and Near Future -- Ready-to-Use Commercial 3D Plates -- Challenges to Adopting 3D Cultures in HTS Programs -- Cases for 3D Cultures in Drug Discovery -- Ideal Case Study Design specialized William S. Kisaalita Includes bibliographical references and index Pharmaceutical biotechnology Biosensors High throughput screening (Drug development) Biosensing Techniques methods Cells, Cultured Drug Discovery 9781420073492 (hardcover : alk. paper) UMP 101213 20251117150251.0 vtls000049203