01617nam a2200253 a 4500001001400000003000700014005001700021008004100038020001800079020001500097040000800112100002400120245011100144260004000255300007300295490004600368504005000414520073900464650002401203650003301227650003801260700001901298830004601317vtls000057260KUKTEM20251117150320.0111212t2010    flua   f      001 0 eng d  a9781420091151  a1420091158  aUMP1 aDoucet, Jean Pierre10aThree dimensional QSAR :bapplications in pharmacology and toxicology /cJean Pierre Doucet, Annick Panaye  aBoca Raton, FL :bCRC Press ,c2010  axxxiv, 533 pages, [8] pages of plates :bill. (some color) ;c24 cm.1 aQSAR in environmental and health sciences  aIncludes bibliographical references and index  a"Experiencing rapid growth over the last 15 years, quantitative structure-activity relationships (QSAR) continue to evolve quickly with an explosion of new tools and techniques. These techniques now play an increasing role in drug design and chemical risk assessment. New molecular descriptors based on three-dimensional structures incorporate a range of classical approaches, including regression and PLS analysis, as well as new nonlinear approaches, such as neural networks and support vector machines. Three-Dimensional QSAR addresses the scope and limitations of different modeling techniques using case studies from pharmacology, toxicology, and ecotoxicology to demonstrate the utility of each technique"--Provided by publisher 0aQSAR (Biochemistry) 0aDrugsxResearchxMethodology 0aToxicologyxResearchxMethodology1 aPanaye, Annick 0aQSAR in environmental and health sciences