02215ntm a2200277 a 4500 vtls000084838 KUKTEM 20251117113253.0 150114t2014 my a f m 000 0 eng d THE0004330(Local) 201905161002 rohana 201712061034 huda 201501140935 fawwaz UMP TP247.5 .S25 2014 r Bc. Siti Salasiah Mohd Khalid Screening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method / Siti Salasiah Mohd Khalid Kuantan, Pahang : UMP, 2014 xiv, 28 p. : ill. ; 30 cm. + 1 CD-ROM Faculty of Chemical & Natural Resources Engineering Project paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014 Bibliography : p. 25-27 A research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of APIs and recognized as the promising alternative to improve APIs properties. Thus, the purpose of this research is to determine the co-crystal formation of carbamazepine-ibuprofen (CBZ-IBU) using stoichiometric methods. In this method, two techniques are used which are solvent evaporation and co-grinding by using ethanol, acetonitrile, ethyl acetate, propanol and formic acid as a solvent. Then, the produced crystal was characterized using differential scanning calorimetry (DSC) and optical microscopy. From this research, it is shown the morphology of the crystals obtained shows prismatic blade like (isometric) morphology indicated that these crystals refer to IBU confirmed by DSC results. The findings concluded that co-crystal was not being able to be formed via these methods of screening Carbamazepine Stoichiometry http://ecollib.ump.edu.my/18363/ Access in library only 0 0 0 1 10000 10000 2019-09-04 0 TP247.5 .S25 2014 r Bc. 0000091667 2019-09-04 00:00:00 1 2019-09-04 PSM 0 0 0 1 10000 10000 2019-09-04 0 CD 8600 | TP247.5 .S25 2014 r Bc. 0000091668 2019-09-04 00:00:00 1 2019-09-04 PSM VIRTUA40 5821 5827 VTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5000*5020*5040*5200*6500*6501*8560*9992