02622nam a2200349 a 4500 vtls000046912 KUKTEM 20251117150443.0 100705t2008 flua f b 001 0 eng d 9780849372681 (hardback : alk. paper) 0849372682 (hardback : alk. paper) 201107132355 VLOAD 201011021526 fauzi 201007051438 shikin UMP RS419.5 .H54 2008 High-throughput lead optimization in drug discovery / edited by Tushar Kshirsagar Boca Raton : CRC Press, c2008 ix, 243 p. : ill. ; 26 cm. Critical reviews in combinatorial chemistry Includes bibliographical references and index Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee High throughput screening (Drug development) Combinatorial chemistry Drug development Combinatorial Chemistry Techniques Drug Design Databases, Genetic Gene Library Kshirsagar, Tushar Critical reviews in combinatorial chemistry Table of contents http://www.loc.gov/catdir/toc/fy0804/2007035804.html 0 0 0 0 10000 10000 2019-09-04 473.54 0 RS419.5 .H54 2008 0000051256 2019-09-04 00:00:00 1 473.54 2019-09-04 OPEN VIRTUA40 58689 58695 VTLSSORT0080*0200*0201*0400*0900*2450*2600*3000*4900*5040*5050*6500*6501*6502*6503*6504*6505*6506*7000*8300*8560*9991