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  <titleInfo>
    <title>High-throughput lead optimization in drug discovery</title>
  </titleInfo>
  <name type="personal">
    <namePart>Kshirsagar, Tushar</namePart>
  </name>
  <typeOfResource>text</typeOfResource>
  <genre authority="marc">bibliography</genre>
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    <place>
      <placeTerm type="text">Boca Raton</placeTerm>
    </place>
    <publisher>CRC Press</publisher>
    <dateIssued>c2008</dateIssued>
    <dateIssued encoding="marc">2008</dateIssued>
    <issuance>monographic</issuance>
  </originInfo>
  <language>
    <languageTerm authority="iso639-2b" type="code">eng</languageTerm>
  </language>
  <physicalDescription>
    <form authority="marcform">print</form>
    <extent>ix, 243 p. : ill. ; 26 cm.</extent>
  </physicalDescription>
  <tableOfContents>Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee</tableOfContents>
  <targetAudience authority="marctarget">specialized</targetAudience>
  <note type="statement of responsibility">edited by Tushar Kshirsagar</note>
  <note>Includes bibliographical references and index</note>
  <subject authority="lcsh">
    <topic>High throughput screening (Drug development)</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Combinatorial chemistry</topic>
  </subject>
  <subject authority="lcsh">
    <topic>Drug development</topic>
  </subject>
  <subject authority="mesh">
    <topic>Combinatorial Chemistry Techniques</topic>
  </subject>
  <subject authority="mesh">
    <topic>Drug Design</topic>
  </subject>
  <subject authority="mesh">
    <topic>Databases, Genetic</topic>
  </subject>
  <subject authority="mesh">
    <topic>Gene Library</topic>
  </subject>
  <relatedItem type="series">
    <titleInfo>
      <title>Critical reviews in combinatorial chemistry</title>
    </titleInfo>
  </relatedItem>
  <identifier type="isbn">9780849372681 (hardback : alk. paper)</identifier>
  <identifier type="isbn">0849372682 (hardback : alk. paper)</identifier>
  <identifier type="uri">http://www.loc.gov/catdir/toc/fy0804/2007035804.html</identifier>
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    <url displayLabel="Table of contents">http://www.loc.gov/catdir/toc/fy0804/2007035804.html</url>
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