03420nam a2200325 a 4500 vtls000046766 KUKTEM 20251117150453.0 100630t2010 njuaf f b 001 0 eng 9780470281741 (cloth) 047028174X (cloth) 201107132358 VLOAD 201011221624 fauzi 201011221623 fauzi 201006301439 faiz UMP QP601.5 .E58 2010 Enzyme inhibition in drug discovery and development : the good and the bad / edited by Chuang Lu, Albert P. Li Hoboken, N.J. : Wiley, c2010 xiii, 854 p., [8] p. of plates : ill. (some col.) ; 25 cm. Includes bibliographical references and index The drug discovery process / Gerald T. Miwa -- Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh -- Bioanalytical technologies in drug discovery / Jing-Tao Wu -- Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk -- The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan -- Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.] -- Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach -- Cytochrome P450 induction / Edward L. LeCluyse ... [et al.] -- Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston -- Enzyme inhibition in various in vitro systems / Ping Zhao -- Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao ... [et al.] -- Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher -- Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu -- Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani -- Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner -- Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang -- Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt -- Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan -- NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang -- G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu -- Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin -- Targeting the mTOR pathway for tumor therapeutics / Wei Chen -- HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat Enzyme inhibitors Drug development Drugs Metabolism Enzyme Inhibitors pharmacology Drug Discovery methods Enzyme Inhibitors chemical synthesis Lu, Chuang Li, A. P. 0 0 0 0 10000 10000 2019-09-04 484.96 0 QP601.5 .E58 2010 0000051851 2019-09-04 00:00:00 1 484.96 2019-09-04 OPEN VIRTUA40 59012 59018 VTLSSORT0080*0200*0201*0400*0900*2450*2600*3000*5040*5050*5051*6500*6501*6502*6503*6504*6505*7000*7001*9991