biologic basis and therapeutics Lyden, David Welch, Danny R. Psaila, Bethan text nyu New York, NY Cambridge University Press 2011 monographic eng

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xvii, 642 p. : ill. (some color) ; 29 cm. Overview: biology is the foundation of therapy / Isaiah J. Fidler; Part I. Basic Research: Introduction to basic research / Harold L. Moses. Models and Tools for Metastasis Studies -- 1. Animal models of cancer metastasis / Janet E. Price -- 2. Drosophilia and zebrafish: genetic models for cancer metastasis / Elisa C. Woodhouse and Kathleen Kelly -- 3. Computational models / Wayne S. Kendal -- 4. Intravital microscopy to visualize invasion and metastasis / Cristina Hidalgo-Carcedo and Erik Sahai. Genes: 5. Metastasis-promoting genes / Devanand Sarkar and Paul B. Fisher -- 6. The role of metastasis suppressor genes in metastasis / Brunilde Gril ... [et al.] -- 7. Stromal-derived factors that dictate organ-specific metastasis / Bedrich L. Eckhardt ... [et al.] -- 8. Metastasis genes: epigenetics / Amaia Lujambio and Manel Esteller -- 9. Germline variation and other host determinants of metastatic potential / Nigel P. S. Crawford and Kent W. Hunter -- 10. The influence of aging and cellular senescence on metastasis / Futoshi Okada and Hiroshi Kobayashi. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer / Lilian Soon ... [et al.} -- 12. Apoptosis, anoikis, and senescence / Wen Liu and Kounosuke Watabe -- 13. Metastatic inefficiency and tumor dormancy / Ann F. Chambers. Stromal cells / Extracellular Matrix: 14. Role of inflammation in metastatic progression / Sunhwa Kim and Michael Karin -- 15. Proteolytic cascades in invasion and metastasis / Steven D. Mason and Johanna A. Joyce -- 16. Role of matrix metalloproteinases in tumor invasion and metastasis / Barbara Fingleton -- 17. Cell- derived microvesicles and metastasis / Hector Peinado, Bethan Psaila and David Lyden. Systemic Factors: specialized edited by David Lyden, Danny R. Welch, Bethan Psaila Includes bibliographical references and index Metastasis 9780521887212 0521887216 UMP 120529 20251125093252.0 vtls000060523