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020			_aTHE0010176 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .J83 2025 r Thesis
100	0		_aJuanni Zhang, _eauthor.
245	1	0	_aFabrication of biocompatible chitin-derived dual-network nanocomposite hydrogels with antibacterial and blood coagulation properties / _cJuanni Zhang
264		1	_aKuantan Pahang : _bUMPSA _c2025
264		4	_c© 2025
300			_axvii, 252 pages : _billustrations ; _c30 cm. + _e1 CD-ROM
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aThesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2025
504			_aIncludes bibliographical references
520	3		_aChitin, the second most abundant natural polysaccharide after cellulose, is a renewable biopolymer composed of β-(1→4)-linked N-acetylglucosamine units. Despite its excellent biocompatibility, degradability, and modifiability, the practical application of chitin remains limited by its poor solubility. Chemical modification can significantly enhance chitin's solubility and functionality, facilitating the research and development of chitin-derived hydrogels. However, chitin-derived hydrogels still encounter challenges such as insufficient mechanical strength, poor biocompatibility, and limited antibacterial properties. To address the limitations, this study integrates dual-network and nanocomposite technologies to develop chitosan/HAp@Zn dual-network nanocomposite hydrogels and quaternized chitosan/chitin nanowhisker dual-network nanocomposite hydrogels, aiming to enhance their properties and broaden their potential applications. The former comprises chitosan, zinc-loaded nano-hydroxyapatite (HAp@Zn), acrylylglycine (ACG), and N-benzylacrylamide (NBAA), while the latter consists of quaternized chitosan (QCS), chitin nanowhiskers (ChWs), acrylic acid, acrylamide, and Zn²+. The influence of the concentration of each component on the properties of the hydrogel was investigated by one-factor-at-a-time analysis, and the structure of the hydrogel was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and scanning electron microscopy (SEM). Additionally, the physical properties (mechanical strength, swelling property, rheological behavior) and biological properties (antibacterial, cytotoxicity, hemolysis, blood coagulation) were systematically examined. The results indicate that the chitosan/HAp@Zn hydrogel possesses excellent mechanical strength and pH-responsive swelling performance. Its maximum mechanical strength is 495.2 kPa and its equilibrium swelling rate is 23.4g/g. The maximum antibacterial rates of E. coli and S. aureus reached 100% and 99.9% respectively. These hydrogels are not cytotoxic and can demonstrate excellent blood compatibility by adjusting their composition. Additionally, they were found to have a good ability for blood coagulation. For the QCS/ChWs hydrogels, the maximum mechanical strength and equilibrium swelling rate are 391.9 kPa and 59.0 g/g, respectively. The maximum antibacterial rates of E. coli and S. aureus were as high as 99.7%. Furthermore, they exhibit superior blood compatibility and no cytotoxicity as well. Most importantly, they show the ability to clot blood rapidly. This study significantly improves the comprehensive properties of chitin-derived hydrogels. It provides an important theoretical basis and technical support for its application in tissue engineering, antibacterial, and hemostatic materials.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
942			_2lcc _cTHESIS
999			_c103795 _d103801