000			02408ntm a2200337 i 4500
003			MY-KuUP
005			20260120155014.0
006			t||||fs|||| 000 0
007			ta
008			260120t20252025my a|||fs|||| 000 0 eng d
020			_aTHE0010289 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFIST .C43 2025 r Bc.
100	0		_aChao Miao Sheng _eauthor.
245	1	0	_aEvaluation of the effects of kyllinga nemoralis cream in rat model of skin-induced allergy / _cChao Miao Sheng
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axii, 69 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Industrial Sciences and Technology
502			_aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aSkin allergies, including atopic dermatitis (AD), are chronic inflammatory conditions that significantly affect quality of life and pose treatment challenges. This study investigates the therapeutic potential of Kyllinga nemoralis extract, known for its anti-inflammatory properties, in a rat model of skin-induced allergy. AD-like lesions were induced using 2,4-dinitrochlorobenzene (DNCB), followed by treatment with K. nemoralis cream at 5% and 10% concentrations. Key metrics, including skin scaling scores, body weight, food intake, and organ weights (liver and kidney), were evaluated. The 5 % cream significantly reduced skin scaling scores from 2.80 ± 0.37 to 1.00 ± 0.00 after 7 days, outperforming the 10% formulation. Liver weights remained unaffected, while untreated lesions showed significantly different in kidney weight, suggesting potential adverse effects of untreated AD. The results, comparable to 1% hydrocortisone cream, indicate K. nemoralis as a promising natural treatment for inflammatory skin conditions. Further studies, including human trials and pharmacokinetic analyses, are recommended to confirm its clinical applicability
610	2	0	_aFaculty of Industrial Sciences and Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aFinal Year Report _xDissertations
942			_2lcc _cPSM
999			_c103896 _d103902