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008			260121t20252025my a|||fs|||| 000 0 eng d
020			_aTHE0010300 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFIST .E55 2025 r Bc.
100	1		_aLau, En Lin, _eauthor.
245	1	0	_aInvestigating the role of complement c3 and c3a in human type 1 diabetes mellitus patients in Malaysia / _cLau En Lin
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axiii, 77 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Industrial Sciences and Technology
502			_aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThe incidence of Type 1 diabetes mellitus (T1DM) has increased globally over the years. Accumulating research suggests that the human complement system may contribute to the pathogenesis of diabetes and induce vascular complications that characterize this condition. Several discoveries from countries such as the UK, China and United States indicated a significant level of complement C3 and C3a in T1DM patients compared to healthy individuals. However, no relevant study has been conducted among T1DM patientsin Malaysia. This study investigates the role of complement C3 and C3a in T1DM patients in Malaysia, with the association of phenotypic characteristics such as age group, ethnicity and gender. A total of 18 (9 T1DM patients and 9 health individuals) were involved in this study and blood serum was obtained for both complement C3 and C3a analysis. The human complement C3 sandwich ELISA kit and human complement C3a sandwich ELISA kit were employed to determine both complement C3 and C3a concentrations in blood serum. The Wilcoxon matched-pairs signed rank test with a Pvalue, 0.1641 for complement C3 and P-value > 0.9999 for complement C3a do not demonstrate any appreciable differences among T1DM patient and healthy control. Based on the findings, the complement C3 and C3a level do not associated with phenotypic characteristics (age, gender and ethnicity) among T1DM patients and healthy controls. As evidence, both Wilcoxon matched-pairs signed rank test (gender) and Kruskal-Wallis tests (age group and ethnicity) were run among T1DM patients and healthy control. P-values obtained (0.3828, 0.1070 and 0.1341) for complement C3 analysis among this group do not show significant differences with these phenotypic characteristics. The results go same with the complement C3a analysis with a P-value of 0.7422 for gender, 0.5283 for age group, and 0.6769 for ethnicity, demonstrating no statistically significant variations based on these phenotypic factors. Therefore, complement C3 and C3a may not be a good indicator in distinguishing between T1DM patient and healthy control in Malaysia.
610	2	0	_aFaculty of Industrial Sciences and Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aFinal Year Report _xDissertations
942			_2lcc _cPSM
999			_c103907 _d103913