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008			260123t20252025my ||| f |||| s0| 0 eng d
020			_aTHE0010305 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFIST .K65 2025 r Bc.
100	1		_aLim, Kok Ling, _eauthor.
245	1	0	_aEvaluation of antibacterial properties and topical application of kyllinga nemoralis extract in allergic-induced skin lesion in rats / _cLim Kok Ling
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axv, 106 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Industrial Sciences and Technology
502			_aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aTraditional medicine as a vital source of healthcare globally, with plants like Kyllinga nemoralis offering significant therapeutic potential. Despite its extensive ethnomedicinal use, the antibacterial efficacy of K. nemoralis, particularly in managing skin allergies complicated by bacterial infections, has not been extensively studied. This study aimed to investigate the antibacterial activity of K. nemoralis and its therapeutic effects in an allergy-induced rat model. To achieve this goal, K. nemoralis methanolic extract was prepared using Soxhlet apparatus, followed by phytochemical analysis via Gas Chromatography-Mass Spectrometry (GC-MS). Antibacterial activity of K. nemoralis was assessed through agar disc diffusion and minimum inhibitory concentration (MIC) assays against Bacillus subtilis and Escherichia coli. A 10% K. nemoralis extract cream was formulated and tested in an-allergy-induced dermatitis rat model, which established using 2,4-dinitrochlorobenzene (DNCB). The extract demonstrated moderate antibacterial activity, with MIC values of 1.88 mg/mL against B. subtilis and 3.75 mg/mL against E. coli. In vivo, the 10% extract cream significantly reduced dermatitis scores of the treatment group from 6.60 to 1.80, indicating its efficacy in combating bacterial infections and alleviating allergic skin conditions. These findings highlighted K. nemoralis as a natural antibacterial agent and a therapeutic option for managing skin infections and allergies
610	2	0	_aFaculty of Industrial Sciences and Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aFinal Year Report _xDissertations
942			_2lcc _cPSM
999			_c103917 _d103923