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008			260123t20252025my a|||fs|||| 000 0 eng d
020			_aTHE0010309 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFIST .M38 2025 r Bc.
100	0		_aPui Ern, Mavis Wong, _eauthor.
245	1	0	_aInvestigating the role of complement c4 in human type 1 diabetes mellitus patients / _cMavis Wong Pui Er
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axiii, 86 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Industrial Sciences and Technology
502			_aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThe complement system is a crucial part of the immune system; it consists of a series of proteins that work together to defend the body against infections. Complement proteins C4 and C4a have been linked to T1DM due to their role in immune response and defence systems. Since no research has been done on the subject in T1DM patients from Malaysia, further investigation is necessary to fully comprehend the potential importance of complement proteins and the role of complement proteins in T1DM. The goal of this study is to investigate the complement concentration using the enzymelinked immunosorbent assay (ELISA) technique, determine the concentration of serum complement C4 and C4a patients with T1DM in Malaysia compared to healthy controls, and investigate the connection between complement protein C4 and C4a with other clinical parameters such as age, gender, and the duration since the disease has been present. To achieve the goals, 9 T1DM patients who met the diagnosis criteria were enlisted, and the blood sample was collected. ELISA is an enzyme-linked immunosorbent assay technique widely used to identify and measure peptides, proteins, antibodies, and hormones. This research uses sandwich ELISA to determine complement protein C4 and C4a concentrations. Based on the findings, we can conclude that the C4 and C4a concentrations do not exhibit significant variation across ethnicities, age groups, and genders within the Malaysian T1DM patient and healthy control. Increasing the sample size may be necessary to improve this experiment's outcomes. A larger sample size enhances the statistical power of the analysis, making it easier to identify significant
610	2	0	_aFaculty of Industrial Sciences and Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aFinal Year Report _xDissertations
942			_2lcc _cRESTRICT
999			_c103921 _d103927