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_aTHE0010324 (Local) _qHardback |
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_aUMPSA _beng _cUMPSA _erda |
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| 090 | _aFIST .P54 2025 r Bc. | ||
| 100 | 1 |
_aP’ng Zhe Hung, _eauthor. |
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| 245 | 1 | 0 |
_aEvaluation of anticancer activities of chistia vespertilionis (red butterfly wing) on breast cancer / _cP’ng Zhe Hung |
| 264 | 1 |
_aKuantan, Pahang : _bUMPSA _c2025 |
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| 264 | 4 | _c© 2025 | |
| 300 |
_axv, 110 pages : _billustrations ; |
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_2rdacontent _atext |
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_2rdamedia _aunmediated |
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_2rdacarrier _avolume |
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_2rda _atext file _bPDF |
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| 500 | _aFaculty of Industrial Sciences and Technology | ||
| 502 | _aFinal Year Report (Bachelor of Applied Science in Industrial Biotechnology) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 | ||
| 504 | _aInclude bibliographical reference | ||
| 520 | 3 | _aBreast cancer is a prominent cause of death in women, highlighting the need for new therapeutic medicines. Christia vespertilionis (C. vespertilionis), which has traditionally been used for its anti-inflammatory and antioxidant effects, may contain bioactive chemicals that can help treat cancer. The anticancer efficacy of C. vespertilionis leaf extracts on MCF-7 breast cancer cells were investigated in vitro using Dichloromethane (DCM) and butanol as solvents. GC-MS study discovered bioactive substances with anticancer and antioxidant effects, including Phytol, 6-tert-Butyl-2,4-dimethylphenol, and n-Hexadecanoic acid. The DCM extract had a higher flavonoid content (0.5435 mg QE/mL), but the butanol extract had a higher phenolic (0.4 mg GAE/mL) and tannin content (0.09071 mg TAE/mL). Cytotoxicity studies revealed dose-dependent effects, with IC50 values of 279.64 µg/mL (DCM) and 269.77 µg/mL (butanol). Apoptotic morphological changes were seen in treated cells. These findings indicate that C. vespertilionis leaf extracts are a potential source of natural anticancer chemicals. | |
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_aFaculty of Industrial Sciences and Technology _xDissertations |
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_aUniversities and colleges _xDissertations |
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_aFinal Year Report _xDissertations |
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| 856 | _uhttp://umpir.ump.edu.my/id/eprint/45705 | ||
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