000			03036ntm a2200349 i 4500
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008			260714t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010725 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .A558 2025 r Bc.
100	0		_aAnith Afiqah Nur ‘izzatul Binti Mohamad Saadun, , , _eauthor.
245	1	0	_aFabrication and characterisation of drug-loaded pla-starch-ncc nanofibers via electrospinning for biomedical applications / _cAnith Afiqah Nur ‘izzatul Binti Mohamad Saadun
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axi, 32 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aTransdermal drug delivery system (TDDS) has been increasingly focused on achieving greater precision and accuracy at the target site compared to traditional methods. Biopolymer nanofibers are promising for drug delivery systems (DDS) due to their biodegradability, high surface area, and biocompatibility. This study focuses on the fabrication and characterization of nanofibers composed of polylactic acid (PLA), starch, and nanocrystalline cellulose (NCC) with varying concentrations (1 wt%, 3 wt%, and 5 wt%) for biomedical applications. PLA is widely utilised due to its biodegradability and biocompatibility, but its inherent brittleness and hydrophobic nature limit its mechanical performance and water adsorption capacity. To address these limitations, starch was incorporated to enhance hydrophilicity, while NCC was added to reinforce mechanical strength and stability. The nanofibers were fabricated using the needleless electrospinning technique and the morphological, chemical, and mechanical properties of the nanofibers were analysed using scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), swelling behaviour, and weight loss analysis. Among the tested formulations, nanofibers with 3 wt% NCC exhibited the larger fiber diameter, swelling resistance, and structural integrity, mitigating PLA’s hydrophobic limitations while maintaining optimal performance. These findings highlight the potential of PLA-starch-NCC nanofibers, particularly at 3 wt% NCC, in developing sustainable and high-performance biomaterials for advanced drug delivery systems.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/45608
942			_2lcc _cPSM
999			_c105211 _d105217