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008			260714t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010728 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .F56 2025 r Bc.
100	1		_aFatin Nur Athirah Binti Mahadi, , , _eauthor.
245	1	0	_aInvestigating the impact of processing attributes towards granule size distribution in high shear wet granulation for tablet manufacturing / _cFatin Nur Athirah Binti Mahadi
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axi, 48 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThe present study will discuss the processing attribute effects on granule size distribution due to high-shear wet granulation, which is an important unit operation within pharmaceutical tablet manufacturing. High-shear wet granulation is generally used to enhance flowability, compressibility, and uniformity of powders in tabletting. These include the four major factors: binder type, binder concentration, impeller speed, and chopper speed, which are systematically studied in this paper using the DOE approach. Riboflavin was used as an active pharmaceutical ingredient, and polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC) were binders. The granules were evaluated for size distribution by sieving, while post-compression analysis included weight variation, hardness, friability, disintegration, and dissolution tests following USP Pharmacopeia specifications. Results showed that binder type and concentration had the most profound influence on granule size and uniformity. Larger and more uniform granules were produced with PVP compared to HPMC. Impeller and chopper speed also played a critical role, particularly in balancing granule size and reducing fines. The optimal conditions improved tablet characteristics like faster disintegration and higher mechanical strength. This study underlines the importance of optimization of processing parameters to enhance product quality, reduce material waste, and support sustainable manufacturing. The results provide valuable insights into the pharmaceutical industry, especially in the development of high-shear wet granulation techniques for better efficiency and consistency in the production of tablets.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47612
942			_2lcc _cPSM
999			_c105214 _d105220