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008			260714t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010729 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .H36 2025 r Bc.
100	0		_aHani Syafiah Binti Abdul Halim, , , _eauthor.
245	1	0	_aEffect of sodium diacetate as semi-synthetic preservative on ascorbic acid syrup properties / _cHani Syafiah Binti Abdul Halim
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_a44 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aVitamin C is the widely used name for ascorbic acid's L-enantiomer. It is an essential nutrient that is crucial to maintaining both human and animal metabolic processes. It's critical to comprehend food preservation methods and spoiling mechanisms to guarantee the ascorbic acid safety and an extended shelf life. Pharmaceutical formulations must contain preservatives to guarantee product stability, safety and shelf life. This research aimed to investigate the impact of various concentrations of sodium diacetate on the physicochemical properties of ascorbic acid syrup. The ascorbic acid syrup is prepared by varying concentrations of semi-synthetic preservatives with concentration of 0.25%, 0.5%,0.75% and 1.0% v/v. Then, four tests were performed within 4 weeks to capture the effects of the preservatives. The performed tests are pH, density, iodometric titration and viscosity assay at five different temperatures (20℃, 27℃, 30℃, 40℃ and 50℃). With possible benefits over conventional synthetic and natural preservatives, sodium diacetate was chosen for its dual function as a pH regulator and preservative. The pH of the ascorbic acid syrup was taken using a Mettler Toledo pH meter, pycnometer is used to take the density, to take the viscosity reading of the sample, Fungilab viscometer is used and iodometric titration is used to know the content of ascorbic acid syrup. Based on these results, sodium diacetate appears to be a feasible semi-synthetic preservative for ascorbic acid syrup that strikes a compromise between product acceptability, safety and efficacy. To evaluate its long-term stability and compatibility with other pharmaceutical excipients, more research is advised. according to the experiment result, optimum concentration of for semi-synthetic is 0.75% v/v. There are no data indicating a significant difference between test results to explain the consequences of using preservatives on the product. To enhance these, it is more useful to have the minimum time of stability test prolonged to 36 months rather than 24 months to understand all the consequences of preservatives on these.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47614
942			_2lcc _cPSM
999			_c105215 _d105221