000			03287ntm a2200349 i 4500
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008			260714t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010731 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .Y44 2025 r Bc.
100	0		_aKuan, Yeh Xi, , , _eauthor.
245	1	0	_aNanofibers fabrication of trigonella foenum graecum extract loaded poly lactic ACID and gelatin with nano cellulose as carrier for antimicrobial applications / _cKuan Yeh Xi
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axi, 71 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThe global challenge of antibiotic resistance demands innovative solutions, particularly in the development of sustainable and biocompatible antimicrobial materials. This study aimed to extract and characterize the antimicrobial properties of Fenugreek, and to fabricate and characterize Fen/PLA/Gel/NCC nanofibers. Fenugreek extract was obtained through maceration and characterized using UV-Vis spectroscopy, confirming the presence of antimicrobial compounds such as phenolic acids, flavonoids, and trigonelline. Nanofibers were fabricated using needleless electrospinning, with the process parameter of height between wire electrode and aluminium foil optimized to produce bead-free nanofibers. Advanced characterization techniques, including SEM, FTIR, TGA, and XRD, were utilized to analyze the morphology, thermal stability, and crystalline structure of the nanofibers. Results demonstrated that the optimized Fen/PLA/Gel/NCC nanofibers exhibited enhanced antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as evidenced by significant inhibition zones. The incorporation of NCC improved the thermal stability of the nanofibers, while the combination of PLA, Gelatin, and Fenugreek extract contributed to their biocompatibility and biodegradability. The best-performing nanofiber was identified with the ratio of Fen/PLA/Gel/NCC at 10:10:0.2:0.1 % w/v, providing the optimal balance of antimicrobial activity, structural integrity, and thermal stability. Recommendations include further optimization of fabrication parameters, comprehensive antimicrobial testing, drug efficiency studies, and isolation of specific bioactive compounds from Fenugreek extract to maximize the nanofiber’s potential. This study underscores the feasibility of Fen/PLA/Gel/NCC nanofibers as an effective solution for antimicrobial applications in healthcare and material science.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47615
942			_2lcc _cPSM
999			_c105217 _d105223