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008			260715t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010735 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .A56 2025 r Bc.
100	0		_aMohammad Aiman Bin Mat Hasim, , , _eauthor.
245	1	0	_aInvestigating the impact of processing attributes toward granule flow properties in high shear wet granulation for tablet manufacturing / _cMohammad Aiman Bin Mat Hasim
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axiv, 75 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThis study investigates the impact of key processing attributes on granule flow properties in high shear wet granulation (HSWG) for tablet manufacturing. The four main attributes examined were impeller speed, chopper speed, binder type, and binder concentration. A two-level factorial design was employed to screen and identify the most significant factors influencing granule flowability. The study utilized riboflavin as the active pharmaceutical ingredient (API), with lactose as the filler, HPMC and PVP as binders, and talc and magnesium stearate as glidant and lubricant, respectively. Experimental results demonstrated that chopper speed, binder type, and binder concentration had a significant impact on granule flowability, whereas impeller speed showed a lesser effect. The findings indicated that PVP at a higher concentration (10%) with a low impeller speed and high chopper speed resulted in superior flow properties. Conversely, HPMC required higher mechanical energy for optimal granule formation due to its strong binding properties. The study also highlighted the importance of optimizing granulation parameters to achieve excellent flowability, ensuring uniform die filling and tablet weight consistency. Overall, this research provides valuable insights into the formulation and process optimization of riboflavin granules, contributing to improved tablet quality and manufacturing efficiency. Future studies could focus on refining these parameters and exploring post-compression characteristics, including tablet hardness, friability, and dissolution profiles, to enhance pharmaceutical product performance.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47620
942			_2lcc _cPSM
999			_c105221 _d105227