000			02628ntm a2200349 i 4500
003			MY-KuUP
005			20260715152633.0
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008			260715t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010740 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .A354 2025 r Bc.
100	0		_aNor Afifah Binti Mohd Nordin, , , _eauthor.
245	1	0	_aAssessment of surface-engineered hyaluronic acid-nano-zeolitic imidazolate framework-8 in the embryo zebrafish model / _cNor Afifah Binti Mohd Nordin
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_ax, 34 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aColon cancer is potentially life-threatening if not detected early. Colon cancer is treatable, typically through surgery which often combines with chemotherapy or radiation therapy yet has many limitations. Hence, to address the limitations of chemotherapy medications, it is significantly crucial for the development of targeted nanosystems that can be highly selective towards cancer cells while enhancing the efficacy and safety of the drug delivery system. In previous research, a zeolitic imidazole framework-8 (ZIF-8), An emerging nanoparticle was suppressed to surface engineered using Hyaluronic Acid (HA) acting as targeting agent for these studies through one-pot solvothermal reaction. The unique characteristics of pristine nano zeolitic imidazole framework-8 (nZIF-8) and Hyaluronic Acid-engineered nano zeolitic imidazole framework-8 (HA@nZIF-8) were assess and execute in of surface area, particle size, newly formed functional groups and surface structure. When modified with the hyaluronic acid, the nano zeolitic imidazole framework-8 likelihood to improve the optimal chemotherapeutic dosage for colon cancer while minimizing unnecessary toxicity towards healthy cell and facilitate higher selective targeting system.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47628
942			_2lcc _cPSM
999			_c105226 _d105232