000			02989ntm a2200349 i 4500
003			MY-KuUP
005			20260724113844.0
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008			260724t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010752 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .H365 2025 r Bc.
100	0		_aNurhanis Binti Adnan, , , _eauthor.
245	1	0	_aKinetic study on drug release from pla-starch-ncc nanofibers fabricated via electrospinning for biomedical applications / _cNurhanis Binti Adnan
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_ax, 52 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aThis study investigates the fabrication and drug release kinetics of polylactic acid (PLA)-starch-nanocrystalline cellulose (NCC) nanofibers loaded with paracetamol, developed using the electrospinning technique for biomedical applications. The primary objective is to study the controlled release of paracetamol and evaluate the suitability of different kinetic models in describing drug release behavior. Various concentrations of starch, NCC, and paracetamol were incorporated into the PLA matrix to determine their effects on nanofiber properties. The nanofibers were characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and UV-Visible Spectroscopy (UV-Vis). Swelling and degradation tests assessed the stability and drug release performance of the nanofibers over time. The drug release kinetics were analyzed using zero-order, first-order, and Higuchi models to determine the most accurate fit. The results indicated that the addition of NCC improved the structural integrity of the nanofibers, while higher paracetamol concentrations accelerated degradation and swelling. The Higuchi model best described the drug release behavior at lower paracetamol concentrations, whereas a combination of zero-order and first-order models provided a better fit for higher concentrations. This study demonstrates the potential of PLA-starch-NCC nanofibers as a sustainable and effective transdermal drug delivery system. Further research should explore in vivo testing and alternative biopolymer formulations to enhance drug release efficiency and biocompatibility.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47661
942			_2lcc _cPSM
999			_c105294 _d105300