000			02921ntm a2200349 i 4500
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008			260724t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010754 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .H53 2025 r Bc.
100	0		_aNurul Hidayah Binti Mohd Zaini, , , _eauthor.
245	1	0	_aExploring stirrer variations in enhancing carbamazepine saccharin cocrystals properties / _cNurul Hidayah Binti Mohd Zaini
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_a34 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aCocrystallization improves drug solubility by connecting hydrogen bonds between the active pharmaceutical ingredients and the coformer. Carbamazepine (CBZ) with solubility problems have been studied with saccharin (SAC) to form cocrystal using cooling crystallization method. Mixing is the main process in cooling crystallization to achieve the desired cocrystal, however the research of the stirrer properties is limited. In this study, different types of stirrer which are turbine, paddle and straight stirrers were used to investigate the impact on the cocrystals. The 1:1 ratio of CBZ:SAC was mixed with ethanol in the crystallizer and cooling crystallization was performed for four cycles. After the fourth cycle, the cocrystals were collected and dried for 24 hours. The characterizations testing were conducted using X-ray Diffraction (XRD), Fourier-transform Infrared Spectroscopy (FTIR) and imaging inverted microscopy. Based on crystallization temperature obtained, the straight stirrer formed the cocrystal fastest while the turbine stirrer formed the cocrystal slowest. The FTIR and XRD analysis revealed that all types of stirrer used successfully formed the carbamazepine saccharin cocrystals, while morphology analysis shows that all the cocrystals behave plate-like shape with different sizes. It was concluded that different types of the stirrer used significantly influenced the crystallization temperature and the size of the cocrystal produced highlighting the importance of stirrer selection to produce cocrystal with desired properties.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47666
942			_2lcc _cPSM
999			_c105296 _d105302