000			02802ntm a2200349 i 4500
003			MY-KuUP
005			20260724154558.0
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008			260724t20252025my a|||fr|||| 000 0 eng d
020			_aTHE0010757 (Local) _qHardback
040			_aUMPSA _beng _cUMPSA _erda
090			_aFTKKP .R33 2025 r Bc.
100	0		_aRabiatul Adawiyah Binti Mohd Adnan, , , _eauthor.
245	1	0	_aFormulation of quercetin tablets: enhancing solubility with polysorbate 20 / _cRabiatul Adawiyah Binti Mohd Adnan
264		1	_aKuantan, Pahang : _bUMPSA, _c2025
264		4	_c© 2025
300			_axi, 57 pages : _billustrations ;
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
338			_2rdacarrier _avolume
347			_2rda _atext file _bPDF
500			_aFaculty of Chemical and Process Engineering Technology
502			_aFinal Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025
504			_aInclude bibliographical reference
520	3		_aQuercetin is a bioactive flavonoid present in different types of plant products, which is famous for antioxidative, anti-inflammatory, and therapeutic actions. However, due to its insolubility in water and very poor bioavailability, its effectiveness as an oral health supplement remains very low. The purpose of this study is to formulate and characterize a quercetin tablet formulation employing polysorbate 20 as a solubility-enhancing excipient. The objectives include determining the solubility, dissolution rate, and physical properties of quercetin tablets following the impact of using varying concentrations of polysorbate 20 at concentrations of 2%, 2.75%, 3.5%, 4.25%, and 5%. The technique includes wet granulation to obtain granules and tablet compression through a single-punch tablet press. Tablet friability, hardness, disintegration, and dissolution tests are performed to check the quality and efficacy of the tablets which are in conformities to USP standards. The focus of this research is to overcome the solubility issues associated with quercetin by formulating a higher-yielding method that improves its pharmacological value. Finally, the best composition of polysorbate 20 for formulation of quercetin tablets was 14% of polysorbate 20. In conclusion, this study provides knowledge in the enhancement of oral drug delivery systems of poorly soluble compounds for better therapeutic outcomes and patient compliance.
610	2	0	_aFaculty of Chemical and Process Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aTheses _xDissertations
856			_uhttps://umpir.ump.edu.my/id/eprint/47715
942			_2lcc _cPSM
999			_c105299 _d105305