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008 111212t2010 my da f m 000 0 eng d
020 _aTHE0002455(Local)
039 9 _a201905271520
_bshamsul
_c201204091059
_dFida
_c201112121431
_dFida
_y201112121202
_zFida
040 _aUMP
090 _aTA418.9.F5 A45 2010 rs Bc.
100 0 _aMohd Amiruddin Fadzli Mohamad Zaini
245 1 0 _aDevelopment of polymeric drug delivery system using electrospun nanofibers for controlled release of multiple proteins /
_cMohd Amiruddin Fadzli Mohamad Zaini
260 _aKuantan, Pahang :
_bUMP,
_c2010
300 _axix, 88 p. :
_bill. (some col.) ;
_c30 cm. +
_e1 CD-ROM
502 _aProject paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2010
504 _aBibliography: p. 81-84
520 3 _aThe purpose of the research is to develop a novel type of drug delivery carrier with the capability of encapsulating multiple drugs and release the drugs in controlled manner. Nanotechnology as a delivery platform offers very promising applications in drug delivery. Polymeric drug delivery devices were successfully developed via electrospinning technique using PCL, PLLA and PLLA-CL biodegradable polymers. Coaxial electrospinning configurations was used to encapsulate three proteins which are BSA, lysozyme and IgG into the electrospun nanofibers. Using the configuration, two separate polymers solutions flowed through two different capillaries which are coaxial with a smaller capillary inside a larger capillary. A number of processing parameters were investigated during the electrospinning process which are formulation of drug loading, the type of polymer and drug and the concentration of polymer and drug. The morphology of the electrospun nanofibers was analyzed using Scanning Electron Microscopy (SEM). The mechanical property was analyzed by using tensile strength and UVSpectrophotometer was used to study the proteins release profile. The results showed that the incorporated proteins could be controlled release by adjusting the process parameters and the proteins structure and bioactivity are maintained. Polymeric drug delivery device is able deliver a pre-determined amount of drug over specific amount of time in a predictable manner. It can improve the effectiveness of drug therapy by increasing the therapeutic activity and reducing the number of drug administrations.
650 0 _aNanofibers
650 0 _aElectrospinning
999 _aVIRTUA40
_c3082
_d3088
999 _aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*9992