000			02088nam a2200265 a 4500
001			vtls000066809
003			KUKTEM
005			20251114204530.0
008			121122t2012 my a f m 000 0 eng d
020			_aTHE0004453(Local)
039		9	_a201905161548 _brohana _y201211221531 _zida
040			_aUMP
090			_aTP248.25.S64 M67 2012 rs Bc.
100	0		_aMorina Mohd Selih
245	1	0	_aOptimization of statin (Simvastatin) by monascus Purpureus FTC 5356 in solid-state fermentation / _ca Morina Mohd Selih
260			_aKuantan, Pahang : _bUMP, _c2012
300			_ax, 66 p. : _bill. ; _c30 cm. + _e1 CD-ROM
502			_aProject paper (Bachelor of Chemical Engineering (Biotechnology)) -- Universiti Malaysia Pahang - 2012
504			_aBibliography : p. 49-54
520	3		_aMonascus sp. is a non-pathogenic fungus that can produce statin called simvastatin that can lower blood cholesterol in human body. The objective of this research is to investigate the optimization condition of the simvastatin production in solid-state fermentation by Monascus purpureus FTC 5356. The local products that used as substrates were banana, guava, pumpkin, coconut meat, corn, papaya and white rice. The fermentation was conducted using the optimum condition of 50% initial moisture content, pH6 at 30°C for 12 days in order to obtain the best substrate. Among these local products, corn can produce the simvastatin while other five fruits do not produce simvastatin. Further experimental carried out using Central Composite Design (CCD) of Response Surface Methodology (RSM) by setting two parameters which are moisture content and nitrogen source by setting the lower and higher range for each of the parameters. From the analysis from RSM, there are 14 runs conducted to achieve the optimum condition to get the maximum production of simvasatin.
650		0	_aSolid-state fermentation
650		0	_aEnzymes _xIndustrial applications
650		0	_aStatins (Cardiovascular agents)
999			_aVIRTUA40 _c3654 _d3660
999			_aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*6502*9992