000			02098nam a2200277 a 4500
001			vtls000023939
003			KUKTEM
005			20251117144455.0
008			080201s2006 gw a f bi 001 0 eng d
020			_a3527314865 (alk. paper)
020			_a9783527314867 (alk. paper)
039		9	_a201201311638 _bida _c201107132237 _dVLOAD _c200908141406 _dVLOAD _c200908141337 _dVLOAD _y200802011131 _znorsaini
040			_aUMP
090			_aRC268.5 .K52 2006
100	1		_aKiaris, Hippokratis
245	1	0	_aUnderstanding carcinogenesis : _ban introduction to the molecular basis of cancer / _cHippokratis Kiaris
260			_aWeinheim : _bWiley-VCH, _cc2006
300			_ax, 177 p. : _bill. ; _c24 cm.
504			_aIncludes bibliographical references and index
505	0		_aSome introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue
650	1	2	_aCell Transformation, Neoplastic _xgenetics
650		0	_aCarcinogenesis _xMolecular aspects.
650		0	_aCancer _xGenetic aspects.
650		0	_aMutation (Biology)
999			_aVIRTUA40 _c37042 _d37048
999			_aVTLSSORT0080*0200*0201*0400*0900*1000*2450*2600*3000*5040*5050*6500*6501*6502*6503*9991