000 02203nam a2200277 a 4500
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008 131025t2013 my da f abm 000 0 eng d
020 _aTHE0003886(Local)
039 9 _a201905161511
_bshah
_y201310251530
_znabilah
040 _aUMP
090 _aTP156.C7 A33 2013 rs Bc.
100 0 _aNur Aida Zakiriah
245 1 0 _aSolid phase transformation of Carbamazepine-Saccharin (CBZ-SAC) co-crystal /
_cNur Aida Zakiriah
260 _aKuantan, Pahang :
_bUMP,
_c2013
300 _axv, 70 p. :
_bill. ;
_c30 cm. +
_e1 CD-ROM
502 _aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2013
504 _aBibliography : p. 51-52
520 3 _aA research was conducted on the solid phase transformation and stability of carbamazepine-saccharin co-crystal. Pharmaceutical co-crystal is one of the potential methods for improving the bioavailibity of drugs with low aqueous solubility. Thus, the purpose of this research is to determine the stable region of carbamazepine-saccharin (CBZ-SAC) co-crystal formation by using solution based method. In this method, three technique are used which are cooling crystallization, solvent evaporation and slurry, to prepare the chemical and use ethanol as a solvent. Different mol ratio of CBZ and SAC are being tested, in order to study CBZ-SAC cocrystal formation. Physical characterizations of the co-crystal are being characterized by differential scanning calorimetry and research microscope. Overall as the concentration of saccharin increase the melting point increase and will lead to poor solubility but mostly the melting point of co-crystal resulting in lower melting point. From this research can be concluded that CBZ-SAC co-crystal can form two forms which are plate-like and needle like. Varying the mol of carbamazepine and used different solvents could be used for further studies to see the difference trending.
650 0 _aCrystallization
650 0 _aDrugs
_xSolubility
650 0 _aCarbamazepine
650 0 _aSaccharin
999 _aVIRTUA40
_c3985
_d3991
999 _aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*6502*6503*9992