000			01874ntm a2200253 a 4500
001			vtls000074588
003			KUKTEM
005			20251114204546.0
008			130923t2012 my da f m 000 0 eng d
020			_aTHE0003894(Local)
039		9	_a201905161506 _bshah _y201309231355 _zhuda
040			_aUMP
090			_aTP156.C7 R64 2012 rs Bc.
100	0		_aMohd Rohaizam Mohd Sidek
245	1	0	_aSolid phase transformation and stability of carbamazepine-adipic acid co-crystal / _cMohd Rohaizam Mohd Sidek
260			_aKuantan, Pahang : _bUMP, _c2012
300			_axii, 69 p. : _bill. (some col.) ; _c30 cm. + _e1 CD-ROM
502			_aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang - 2012
504			_aBibliography : p. 53
520	3		_aCo-crystal is a mixed crystal or crystal that contains two or more different molecules. In this study, the solid phase transformation of CBZ-AA co-crystal and solubility of carbamazepine (CBZ) and adipic acid (AA) is examined. In this dissertation, the solubility of CBZ and AA via HPLC and gravimetric methods are reported. On the other hand, the study of solid phase transformation is planned to proceed via slurry co-crystallization method. The result shows the solubility of CBZ and AA via gravimetric and HPLC method is increased as the temperature increased from 25 ˚C to 50 ˚C. TGA analysis shows the weight changed of CBZ is 96.21 % at decomposed temperature of 250 ˚C and 94.47 % for AA at 220 ˚C decomposed temperature. The wavenumbers corresponding to CBZ and AA is obtained from FTIR analysis. Due to time limitation, the phase transformation of CBZ-AA co-crystal is suggested to be continued by another student in the future.
650		0	_aCrystallization
650		0	_aAdipic acid
999			_aVIRTUA40 _c4095 _d4101
999			_aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*9992