| 000 | 02730nam a2200277 a 4500 | ||
|---|---|---|---|
| 001 | vtls000076091 | ||
| 003 | KUKTEM | ||
| 005 | 20251114204550.0 | ||
| 008 | 131113t2013 my da f m 000 0 eng d | ||
| 020 | _aTHE0004329(Local) | ||
| 039 | 9 |
_a201905160958 _brohana _y201311131453 _znabilah |
|
| 040 | _aUMP | ||
| 090 | _aTP247.5 .H33 2013 rs Bc. | ||
| 100 | 0 | _aMuhamad Hadi Sulaiman | |
| 245 | 1 | 0 |
_aSolvent screening study of carbamazepine crystal polymorph / _cMuhamad Hadi Sulaiman |
| 260 |
_aKuantan, Pahang : _bUMP, _c2013 |
||
| 300 |
_axv, 53 p. : _bill. ; _c30 cm. + _e1 CD-ROM |
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| 502 | _aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2013 | ||
| 504 | _aBibliography : p. 48-51 | ||
| 520 | 3 | _aRealizing solvents can be paramount critical and important in crystallizing specific polymorphs, complete manual, references, method and approach in predicting the polymorph formed from the specific parameter need to be developed. Solvent screening is the process of determining the relation between solvent choose and respective crystal form mainly focused on the solubility and its related properties. For this particular research, the approaches is by choosing specific properties of solvent used to find the relationship between them to relate with the crystallize structure formed. Polarity, hydrogen-donor-acceptor, and dipole moment is known to give much effect on the polymorph formation. By selecting the solvent with distinct properties considering its polarity, hydrogen-donor-acceptor, and dipole moment, the carbamazepine will be dissolve and recrystallize. Gravimetric method was used to determine the solubility of carbamazepine. DSC and optical microscopes was used to characterize the polymorph. Van `t Hoff plot was constructed from the solubility data and the stability prediction was made based on the free energy value calculated. It is found that weak interaction of solvent-solute will result in more stable polymorph but not necessarily correct because other factor such as temperature need to be consider during dissolution and crystallization process. One solvent having a tendency to produce more than one type of polymorph depend on the temperature of dissolution. Morphology of carbamazepine polymorph inconsistent for several trials and can be change easily through the process. This result will be potential additional reference for more perfect approaches in the future especially for molecular dynamic simulation. | |
| 650 | 0 | _aCarbamazepine | |
| 650 | 0 | _aCrystallography | |
| 650 | 0 | _aPolymorphism (Crystallography) | |
| 650 | 0 | _aSolvents | |
| 999 |
_aVIRTUA40 _c4204 _d4210 |
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| 999 | _aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5020*5040*5200*6500*6501*6502*6503*9992 | ||