000			02094ntm a2200265 a 4500
001			vtls000084820
003			KUKTEM
005			20251117113230.0
008			150113t2014 my a f m 000 0 eng d
020			_aTHE0003892(Local)
039		9	_a201905161507 _bshah _y201501131300 _zfawwaz
040			_aUMP
090			_aTP156.C7 N33 2014 r Bc.
100	0		_aEngku Nadia Engku Mat Nasir
245	1	0	_aSolid phase transformation of carbamazepine-succinic co-crystal / _cEngku Nadia Engku Mat Nasir
260			_aKuantan, Pahang : _bUMP, _c2014
300			_axv, 37 p. : _bill. ; _c30 cm. + _e1 CD-ROM
500			_aFaculty of Chemical & Natural Resources Engineering
502			_aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014
504			_aBibliography : p. 28-31
520	3		_aThis paper presents the solid phase transformation of carbamazepine-succinic co-crystal. Solvent evaporation, slurry crystallization and cooling crystallization are the three techniques which represent the solution based method were used. In this study ethanol was used as solvent. CBZ-SUC co-crystals formations are studied by varying the mol ratio of CBZ and SUC. The CBZ-SUC co-crystals formation was characterized by using X-ray powder diffraction (XRPD), and optical microscopy. From the XRPD pattern profile, it shows that the co-crystals were formed for all the ratio of CBZ and SUC by the slurry crystallization and cooling crystallization. The results shows that the pattern profiles representing the co-crystal as no peak are develop with the raw material peak. The morphology of the co-crystals formation is needle-like co-crystals for cooling crystallization and solvent evaporation. The morphology of slurry crystallization is difficult to characterize due to agglomeration effects. Results from this research may be useful in pharmaceutical industry as the co-crystals are successfully formed
650		0	_aCrystallization
650		0	_aCarbamazepine
999			_aVIRTUA40 _c5117 _d5123
999			_aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5000*5020*5040*5200*6500*6501*9992