| 000 | 02439nam a2200301 a 4500 | ||
|---|---|---|---|
| 001 | vtls000049203 | ||
| 003 | KUKTEM | ||
| 005 | 20251117150251.0 | ||
| 008 | 101213t2010 flua f b 001 0 eng d | ||
| 020 | _a9781420073492 (hardcover : alk. paper) | ||
| 039 | 9 |
_a201107140005 _bVLOAD _c201103170806 _dFida _c201103091511 _dfauzi _y201012131502 _ztraining |
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| 040 | _aUMP | ||
| 090 | _aRS380 .K57 2010 | ||
| 100 | 1 | _aKisaalita, William Ssempa | |
| 245 | 1 | 0 |
_a3D cell-based biosensors in drug discovery programs : _bmicrotissue engineering for high throughput screening / _cWilliam S. Kisaalita |
| 260 |
_aBoca Raton : _bCRC Press, _c2010 |
||
| 300 |
_axvii, 386 p. : _bill. ; _c24 cm. |
||
| 504 | _aIncludes bibliographical references and index | ||
| 505 | 8 | _a(Publisher-supplied data) Biosensors and Bioassays -- Target-Driven Drug Discovery -- Comparative Genomics and Proteomics -- Comparative Structure and Function -- Chemical Microenvironmental Factors -- Spatial and Temporal Microenvironmental Factors -- Material Physical Property and Force Microenvironmental Factors -- Proteomics as a Promising Tool in the Search for 3D Biomarkers -- Readout Present and Near Future -- Ready-to-Use Commercial 3D Plates -- Challenges to Adopting 3D Cultures in HTS Programs -- Cases for 3D Cultures in Drug Discovery -- Ideal Case Study Design | |
| 520 | _a"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher | ||
| 650 | 0 | _aPharmaceutical biotechnology | |
| 650 | 0 | _aBiosensors | |
| 650 | 0 | _aHigh throughput screening (Drug development) | |
| 650 | 1 | 2 |
_aBiosensing Techniques _xmethods |
| 650 | 2 | 2 | _aCells, Cultured |
| 650 | 2 | 2 | _aDrug Discovery |
| 999 |
_aVIRTUA40 _c54850 _d54856 |
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