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008 150114t2014 my a f m 000 0 eng d
020 _aTHE0004330(Local)
039 9 _a201905161002
_brohana
_c201712061034
_dhuda
_y201501140935
_zfawwaz
040 _aUMP
090 _aTP247.5 .S25 2014 r Bc.
100 0 _aSiti Salasiah Mohd Khalid
245 1 0 _aScreening of carbamazepine-ibuprofen (cbz-ibu) co-crystal formation using stoichiometric method /
_cSiti Salasiah Mohd Khalid
260 _aKuantan, Pahang :
_bUMP,
_c2014
300 _axiv, 28 p. :
_bill. ;
_c30 cm. +
_e1 CD-ROM
500 _aFaculty of Chemical & Natural Resources Engineering
502 _aProject paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2014
504 _aBibliography : p. 25-27
520 3 _aA research was conducted on the screening of carbamazepine-ibuprofen co-crystal formation using stoichiometric method via co-grinding and solvent evaporation. Pharmaceutical co-crystals formation have been proven useful in enhancing the solubility, dissolution rate, stability, and bioavailability of APIs and recognized as the promising alternative to improve APIs properties. Thus, the purpose of this research is to determine the co-crystal formation of carbamazepine-ibuprofen (CBZ-IBU) using stoichiometric methods. In this method, two techniques are used which are solvent evaporation and co-grinding by using ethanol, acetonitrile, ethyl acetate, propanol and formic acid as a solvent. Then, the produced crystal was characterized using differential scanning calorimetry (DSC) and optical microscopy. From this research, it is shown the morphology of the crystals obtained shows prismatic blade like (isometric) morphology indicated that these crystals refer to IBU confirmed by DSC results. The findings concluded that co-crystal was not being able to be formed via these methods of screening
650 0 _aCarbamazepine
650 0 _aStoichiometry
856 4 0 _uhttp://ecollib.ump.edu.my/18363/
_zAccess in library only
999 _aVIRTUA40
_c5821
_d5827
999 _aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5000*5020*5040*5200*6500*6501*8560*9992