| 000 | 02622nam a2200349 a 4500 | ||
|---|---|---|---|
| 001 | vtls000046912 | ||
| 003 | KUKTEM | ||
| 005 | 20251117150443.0 | ||
| 008 | 100705t2008 flua f b 001 0 eng d | ||
| 020 | _a9780849372681 (hardback : alk. paper) | ||
| 020 | _a0849372682 (hardback : alk. paper) | ||
| 039 | 9 |
_a201107132355 _bVLOAD _c201011021526 _dfauzi _y201007051438 _zshikin |
|
| 040 | _aUMP | ||
| 090 | _aRS419.5 .H54 2008 | ||
| 245 | 0 | 0 |
_aHigh-throughput lead optimization in drug discovery / _cedited by Tushar Kshirsagar |
| 260 |
_aBoca Raton : _bCRC Press, _cc2008 |
||
| 300 |
_aix, 243 p. : _bill. ; _c26 cm. |
||
| 490 | 1 | _aCritical reviews in combinatorial chemistry | |
| 504 | _aIncludes bibliographical references and index | ||
| 505 | 0 | _aApplication of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings -- Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht -- A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini -- How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li -- Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh -- Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie -- Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu -- High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee | |
| 650 | 0 | _aHigh throughput screening (Drug development) | |
| 650 | 0 | _aCombinatorial chemistry | |
| 650 | 0 | _aDrug development | |
| 650 | 1 | 2 | _aCombinatorial Chemistry Techniques |
| 650 | 1 | 2 | _aDrug Design |
| 650 | 2 | 2 | _aDatabases, Genetic |
| 650 | 2 | 2 | _aGene Library |
| 700 | 1 | _aKshirsagar, Tushar | |
| 830 | 0 | _aCritical reviews in combinatorial chemistry | |
| 856 | 4 | 1 |
_3Table of contents _uhttp://www.loc.gov/catdir/toc/fy0804/2007035804.html |
| 999 |
_aVIRTUA40 _c58689 _d58695 |
||
| 999 | _aVTLSSORT0080*0200*0201*0400*0900*2450*2600*3000*4900*5040*5050*6500*6501*6502*6503*6504*6505*6506*7000*8300*8560*9991 | ||