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003			KUKTEM
005			20251117150453.0
008			100630t2010 njuaf f b 001 0 eng
020			_a9780470281741 (cloth)
020			_a047028174X (cloth)
039		9	_a201107132358 _bVLOAD _c201011221624 _dfauzi _c201011221623 _dfauzi _y201006301439 _zfaiz
040			_aUMP
090			_aQP601.5 .E58 2010
245	0	0	_aEnzyme inhibition in drug discovery and development : _bthe good and the bad / _cedited by Chuang Lu, Albert P. Li
260			_aHoboken, N.J. : _bWiley, _cc2010
300			_axiii, 854 p., [8] p. of plates : _bill. (some col.) ; _c25 cm.
504			_aIncludes bibliographical references and index
505	0		_aThe drug discovery process / Gerald T. Miwa -- Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh -- Bioanalytical technologies in drug discovery / Jing-Tao Wu -- Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk -- The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan -- Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.] -- Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach -- Cytochrome P450 induction / Edward L. LeCluyse ... [et al.] -- Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston -- Enzyme inhibition in various in vitro systems / Ping Zhao -- Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao ... [et al.] -- Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher --
505	0		_aEvaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu -- Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani -- Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner -- Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang -- Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt -- Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan -- NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang -- G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu -- Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin -- Targeting the mTOR pathway for tumor therapeutics / Wei Chen -- HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat
650		0	_aEnzyme inhibitors
650		0	_aDrug development
650		0	_aDrugs _xMetabolism
650	1	2	_aEnzyme Inhibitors _xpharmacology
650	2	2	_aDrug Discovery _xmethods
650	2	2	_aEnzyme Inhibitors _xchemical synthesis
700	1		_aLu, Chuang
700	1		_aLi, A. P.
999			_aVIRTUA40 _c59012 _d59018
999			_aVTLSSORT0080*0200*0201*0400*0900*2450*2600*3000*5040*5050*5051*6500*6501*6502*6503*6504*6505*7000*7001*9991