000			03162ntm a2200289 a 4500
001			vtls000093797
003			KUKTEM
005			20251117113322.0
008			160314t2015 my a f 000 0 eng d
020			_aTHE0000966(Local)
039		9	_a201905271113 _bnazirah _c201711301108 _dfateeha _y201603141131 _zhuda
040			_aUMP
090			_aFKKSA .N67 2015 r Bc.
100	0		_aNoraini Ghazali
245	1		_aTransformation of carbamazepine dihydrate to anhydrous carbamazepine / _cNoraini Ghazali
260			_aKuantan, Pahang : _bUMP, _c2015
300			_axiv, 56 p. : _bill. ; _c30 cm. + _e1 CD-ROM
500			_aFaculty of Chemical & Natural Resources Engineering
502			_aProject Paper (Bachelor of Chemical Engineering) -- Universiti Malaysia Pahang – 2015
504			_aBibliography : p. 32-34
520	3		_aAn investigation of carbamazepine dihydrate transformation to anhydrous carbamazepine was presented. In this works, carbamazepine dihydrate and solvents (ethanol, methanol, propanol, acetonitrile, ethyl acetate and methyl acetate) were used. The crystallization process was conducted using different solvents by applying solid state method using differential scanning calorimetry analysis and solution based method. For solution based method, three conditions of the experiment were implemented i.e. dissolution with heating and cooling without stirring, dissolution with heating and cooling with stirring, dissolution with heating and stirring followed by cooling without stirring. Solid state characterization of the crystals were analysed using Differential Scanning Calorimetry (DSC) and Powder XRay Diffraction (PXRD). Analysis data obtained from DSC revealed that the crystals produced from the transformation of carbamazepine dihydrate to anhydrous carbamazepine using solid state and solution based method were not successful. From DSC analysis, themelting point of carbamazepine dihydrate with six solvents for both methods were in the range of 70-160oC. The finding from DSC analysis showed that the melting point of crystals did not fall within the melting point value of the anhydrous form. Referring to the PXRD analysis, the pattern profile of carbamazepine in six solvents with three different conditions does not similar to the literature for the indicative peaks of anhydrous form. It was suggestedthat the crystals obtained from the dissolution of carbamazepine dihydrate with six solventsusing three different conditions were unsuccessful to transform carbamazepine dihydrate to anhydrous carbamazepine. Further study using different techniques and conditions were suggested in order to study the transformation of carbamazepine dihydrate to anhydrous carbamazepine.
610	2	0	_aFaculty of Chemical & Natural Resources Engineering _xDissertations
650		0	_aUniversities and Colleges _xDissertations
650		0	_aTheses
856	4	0	_uhttp://ecollib.ump.edu.my/id/eprint/25973 _zAccess in library only
999			_aVIRTUA40 _c6651 _d6657
999			_aVTLSSORT0080*0200*0400*0900*1000*2450*2600*3000*5000*5020*5040*5200*6100*6500*6501*8560*9992