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| 001 | vtls000105336 | ||
| 003 | KUKTEM | ||
| 005 | 20251117113407.0 | ||
| 008 | 180928t20182018my da f a m 001 0 eng d | ||
| 020 | _aTHE0000105(Local) | ||
| 039 | 9 |
_a201905311453 _bnazirah _y201809281005 _zfateeha |
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_aUMP _beng _cUMP _erda |
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| 090 | _aFIST .A33 2018 r Thesis | ||
| 100 | 0 |
_aAddila Abu Bakar, _eauthor. |
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| 245 | 1 | 0 |
_aDesign, synthesis of flavokawain b derivative and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines / _cAddila Abu Bakar |
| 264 | 1 |
_aKuantan, Pahang : _bUMP, _c2018 |
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| 264 | 4 | _c© 2018 | |
| 300 |
_axxii, 160 pages : _billustrations, charts ; _c30 cm. + _e1 CD-ROM |
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_atext _2rdacontent |
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_aunmediated _2rdamedia |
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_acomputer _2rdamedia |
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_avolume _2rdacarrier |
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_acomputer disc _2rdacarrier |
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_atext file _bPDF _2rda |
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| 500 | _aFaculty of Industrial Sciences and Technology | ||
| 502 | _aThesis (Master of Science) -- Universiti Malaysia Pahang – 2018 | ||
| 504 | _aIncludes bibliographical references | ||
| 520 | 3 | _aCancer is among the cause of death whereof breast cancer is the second leading cause of cancer death among women worldwide. Cancer treatment with standard anti-cancer drug, chemotherapy and radiation have caused unwanted side effects in the patient. Therefore chalcone with many pharmacological benefits such as anti-cancer, anti-mitotic, etc., has gained attention as a subject of research. Flavokawain B derivative chalcones bearing methoxy, dimethoxy, trimethoxy, bromo, chloro, fluoro, methyl, methylthio, nitro, hydroxyl and dimethylamino groups on benzaldehyde were synthesized via Claisen-Schmidt condensation method using base catalyst; the synthesized compounds were characterized by using UV-Visible, Fourier Transform Infrared spectrophotometry (FTIR), Gas Chromatography-Mass Spectrometry (GC-MS) and Nuclear Magnetic Resonance (NMR) spectrometry and evaluated for their cytotoxicity against breast cancer cell line by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in vitro. Among 22 synthesized compounds, two compounds, 80 and 91 have been discovered as new flavokawain B analogs and some compounds showed good anti-cancer activity following the cut-off point value, IC50 is less than 30 μg/mL. The compounds are chalcone 4 (7.70 ± 0.30 μg/mL), 5 (8.90 ± 0.60 μg/mL), 75 (12.30 ± 1.40 μg/mL), 79 (6.50 ± 0.40 μg/mL), 80 (7.12 ± 0.80 μg/mL), 82 (9.70 ± 0.70 μg/mL), 84 (5.50 ± 0.35 μg/mL), 85 (8.43 ± 0.40 μg/mL), 44 (13.30 ± 3.10 μg/mL) and 91 (6.50 ± 0.35 μg/mL) that exhibited good anti-cancer activity against MCF-7. Chalcone 4 (5.90 ± 0.30 μg/mL), 5 (6.80 ± 0.45 μg/mL), 75 (18.10 ± 1.10 μg/mL), 79 (4.12 ± 0.20 μg/mL), 80 (4.04 ± 0.30 μg/mL), 81 (9.50 ± 0.60 μg/mL), 82 (8.30 ± 0.56 μg/mL), 84 (5.50 ± 0.40 μg/mL), 85 (7.22 ± 0.70 μg/mL) and 44 (17.10 ± 2.15 μg/mL) showed good anti-cancer activity against MDA-MB-231 as well as compound 79 and 80 was discovered to be more active than the reference drug doxorubicin (5.05 ± 0.20 μg/mL). Structure-activity relationship study suggested that significantly improved cytotoxicity was shown by halogenated flavokawain B, followed by methoxylated flavokawain B, particularly when substitution occurred at position 2 and 3 in ring B. | |
| 610 | 2 | 0 |
_aFaculty of Industrial Sciences and Technology _xDissertations |
| 650 | 0 |
_aUniversities and colleges _xDisertations |
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| 650 | 0 | _aTheses | |
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_aVIRTUA40 _c7885 _d7891 |
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| 999 | _aVTLSSORT0080*0200*0400*0900*1000*2450*2640*2641*3000*3360*3361*3370*3371*3380*3381*3470*5000*5020*5040*5200*6100*6500*6501*9992 | ||