000			03868nam a2200373 i 4500
999			_c99551 _d99557
003			MY-KuUP
005			20251125110741.0
006			a||||fr|||| 000 0
007			ta
008			230614t20232023my a|||fr|||| 000 0 eng d
020			_aTHE0009474 (Local) _qHardback
040			_aUMP _beng _cUMP _erda
090			_aFTKEE .M39 2023 r Thesis
100	1		_aMazuina Mohamad, _eauthor.
245	1	2	_aA development of an optical bilirubin detection system In the visible (vis) region for jaundice diagnosis application / _cMazuina Mohamad
264		1	_aPahang : _bUMP, _c2023
264		4	_c© 2023
300			_axiv, 115 pages : _e1 CD ROM _bIllustration ; _c30 cm.+
336			_2rdacontent _atext
336			_2rdacontent _atext
337			_2rdamedia _aunmediated
337			_2rdamedia _acomputer
338			_2rdacarrier _avolume
338			_2rdacarrier _acomputer disc
347			_2rda _atext file _bPDF
500			_aFaculty of Electrical & Electronics Engineering Technology
502			_aThesis (Doctor of Philosophy) -- Universiti Malaysia Pahang – 2023
504			_aIncludes bibliographical reference
520	3		_aThis thesis describes the development of an optical fibre sensor for the detection of bilirubin (BR) molecules and measurement of its concentration in the visible (Vis) wavelength region. The concentration which exceeds the normal rate of BR in the human body that can lead to jaundice, and severe of hyperbilirunemia to newborns. Current practices have drawbacks which take longer of time to produce results. Some of the existence techniques are based on the consumption of other element for measuring the BR concentration in the sample. So that, BR molecules is mixed with a particular substance which can give effects to the identification and concentration measurement of BR. This research is carried out to identify the optimum absorption of BR molecules and analyses a cross sensitivity issue which is arise as a BR concentration measurement system based on spectroscopy study. It was developed using an open-path technique where the analytical sample is tested through the transmitting UV-Visible light beam. The experimental setup consists of halogen light source, cuvette holder, cuvette (cell), optical fibre cables and computer to display results. The Spectrasuite software was used in initial set up to display the optimum absorbance of BR. This software was irrelevant to measure the BR concentration in real-time. Therefore, LabVIEW can be used for this purpose. The developed optical sensor was successfully optimized. It is able to measure the various concentration of the four samples which are 50 μmol/L, 100 μmol/L, 150 μmol/L and 200 μmol/L at the particular visible absorption peak at 440 nm with low noise signal. Ratio technique was implemented to solve the cross-sensitivity issue between the BR molecules and Hemoglobin (Hb). Otherwise, the cross-sensitivity issue between carbon dioxide and oxygen can be ignored due to the very low absorption in the visible region. The developed BR concentration measurement system was also compared with the commercial set up system. It is associated with each concentration. It is also defined as a correlation between the measured absorbance produced by both instruments. The error percentage showed less than 3% which is considered as a laboratory standard for the instrument with good precision. By the advantage of LabVIEW, the optical sensor has an ability to measure the BR concentrations in real-time. This is a good potential that the optical sensor can identify the BR molecules and measure its concentration in a fast time response which is around 3s.
610	2	0	_aFaculty of Electrical & Electronics Engineering Technology _xDissertations
650		0	_aUniversities and colleges _xDissertations
650		0	_aThesis _xDissertations
942			_2lcc _cTHESIS