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Kinetic study on drug release from pla-starch-ncc nanofibers fabricated via electrospinning for biomedical applications / Nurhanis Binti Adnan

By:

Nurhanis Binti Adnan, , [author.]

Material type: Text

text

Media type:

unmediated

Carrier type:

volume

ISBN:

THE0010752 (Local)

Subject(s):

Online resources:

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Dissertation note: Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: This study investigates the fabrication and drug release kinetics of polylactic acid (PLA)-starch-nanocrystalline cellulose (NCC) nanofibers loaded with paracetamol, developed using the electrospinning technique for biomedical applications. The primary objective is to study the controlled release of paracetamol and evaluate the suitability of different kinetic models in describing drug release behavior. Various concentrations of starch, NCC, and paracetamol were incorporated into the PLA matrix to determine their effects on nanofiber properties. The nanofibers were characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and UV-Visible Spectroscopy (UV-Vis). Swelling and degradation tests assessed the stability and drug release performance of the nanofibers over time. The drug release kinetics were analyzed using zero-order, first-order, and Higuchi models to determine the most accurate fit. The results indicated that the addition of NCC improved the structural integrity of the nanofibers, while higher paracetamol concentrations accelerated degradation and swelling. The Higuchi model best described the drug release behavior at lower paracetamol concentrations, whereas a combination of zero-order and first-order models provided a better fit for higher concentrations. This study demonstrates the potential of PLA-starch-NCC nanofibers as a sustainable and effective transdermal drug delivery system. Further research should explore in vivo testing and alternative biopolymer formulations to enhance drug release efficiency and biocompatibility.

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Title notes ( 4 )

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	FTKKP .H365 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000004346

Faculty of Chemical and Process Engineering Technology

Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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This study investigates the fabrication and drug release kinetics of polylactic acid (PLA)-starch-nanocrystalline cellulose (NCC) nanofibers loaded with paracetamol, developed using the electrospinning technique for biomedical applications. The primary objective is to study the controlled release of paracetamol and evaluate the suitability of different kinetic models in describing drug release behavior. Various concentrations of starch, NCC, and paracetamol were incorporated into the PLA matrix to determine their effects on nanofiber properties. The nanofibers were characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and UV-Visible Spectroscopy (UV-Vis). Swelling and degradation tests assessed the stability and drug release performance of the nanofibers over time. The drug release kinetics were analyzed using zero-order, first-order, and Higuchi models to determine the most accurate fit. The results indicated that the addition of NCC improved the structural integrity of the nanofibers, while higher paracetamol concentrations accelerated degradation and swelling. The Higuchi model best described the drug release behavior at lower paracetamol concentrations, whereas a combination of zero-order and first-order models provided a better fit for higher concentrations. This study demonstrates the potential of PLA-starch-NCC nanofibers as a sustainable and effective transdermal drug delivery system. Further research should explore in vivo testing and alternative biopolymer formulations to enhance drug release efficiency and biocompatibility.