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Formulation of quercetin tablets: enhancing solubility with polysorbate 20 / Rabiatul Adawiyah Binti Mohd Adnan

By:

Rabiatul Adawiyah Binti Mohd Adnan, , [author.]

Material type: Text

text

Media type:

unmediated

Carrier type:

volume

ISBN:

THE0010757 (Local)

Subject(s):

Online resources:

Click here to access online

Dissertation note: Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025 Abstract: Quercetin is a bioactive flavonoid present in different types of plant products, which is famous for antioxidative, anti-inflammatory, and therapeutic actions. However, due to its insolubility in water and very poor bioavailability, its effectiveness as an oral health supplement remains very low. The purpose of this study is to formulate and characterize a quercetin tablet formulation employing polysorbate 20 as a solubility-enhancing excipient. The objectives include determining the solubility, dissolution rate, and physical properties of quercetin tablets following the impact of using varying concentrations of polysorbate 20 at concentrations of 2%, 2.75%, 3.5%, 4.25%, and 5%. The technique includes wet granulation to obtain granules and tablet compression through a single-punch tablet press. Tablet friability, hardness, disintegration, and dissolution tests are performed to check the quality and efficacy of the tablets which are in conformities to USP standards. The focus of this research is to overcome the solubility issues associated with quercetin by formulating a higher-yielding method that improves its pharmacological value. Finally, the best composition of polysorbate 20 for formulation of quercetin tablets was 14% of polysorbate 20. In conclusion, this study provides knowledge in the enhancement of oral drug delivery systems of poorly soluble compounds for better therapeutic outcomes and patient compliance.

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Title notes ( 4 )

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Final Year Report	UMPLIB GAMBANG	FTKKP .R33 2025 r Bc. (Browse shelf(Opens below))	Not for loan		T000004351

Faculty of Chemical and Process Engineering Technology

Final Year Report (Bachelor of Manufacturing Engineering Technology (Pharmaceuticals) with Hons ) -- Universiti Malaysia Pahang Al-Sultan Abdullah - 2025

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Quercetin is a bioactive flavonoid present in different types of plant products, which is famous for antioxidative, anti-inflammatory, and therapeutic actions. However, due to its insolubility in water and very poor bioavailability, its effectiveness as an oral health supplement remains very low. The purpose of this study is to formulate and characterize a quercetin tablet formulation employing polysorbate 20 as a solubility-enhancing excipient. The objectives include determining the solubility, dissolution rate, and physical properties of quercetin tablets following the impact of using varying concentrations of polysorbate 20 at concentrations of 2%, 2.75%, 3.5%, 4.25%, and 5%. The technique includes wet granulation to obtain granules and tablet compression through a single-punch tablet press. Tablet friability, hardness, disintegration, and dissolution tests are performed to check the quality and efficacy of the tablets which are in conformities to USP standards. The focus of this research is to overcome the solubility issues associated with quercetin by formulating a higher-yielding method that improves its pharmacological value. Finally, the best composition of polysorbate 20 for formulation of quercetin tablets was 14% of polysorbate 20. In conclusion, this study provides knowledge in the enhancement of oral drug delivery systems of poorly soluble compounds for better therapeutic outcomes and patient compliance.