Enzyme inhibition in drug discovery and development : the good and the bad / edited by Chuang Lu, Albert P. Li

Includes bibliographical references and index

The drug discovery process / Gerald T. Miwa -- Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh -- Bioanalytical technologies in drug discovery / Jing-Tao Wu -- Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk -- The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan -- Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.] -- Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach -- Cytochrome P450 induction / Edward L. LeCluyse ... [et al.] -- Inhibition of drug-metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston -- Enzyme inhibition in various in vitro systems / Ping Zhao -- Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao ... [et al.] -- Complexities of working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher --

Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu -- Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani -- Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner -- Polymorphisms of drug transporters and their clinical implications / Cindy Q. Xia and Johnny J. Yang -- Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt -- Predicting interindividual variability of metabolic drug-drug interactions : identifying the causes and accounting for them using a systems approach / Amin Rostami-Hodjegan -- NF-kB : mechanism, tumor biology, and inhibitors / Lenny Dang -- G-protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu -- Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin -- Targeting the mTOR pathway for tumor therapeutics / Wei Chen -- HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat